Regulation of Urokinase/Urokinase Receptor Interaction by Heparin-like Glycosaminoglycans
نویسندگان
چکیده
منابع مشابه
Regulation of proBACEl by Glycosaminoglycans
The !3-secretase (BACE1) is initially synthesized as a partially act ive zymogen contain ing a prodomain which can be furthe r activated th rough proteolytic cleavage of the prodomain by a fu rin-Iike protease.The active site of BACEl is large and although a number of high-affinity active-site inh ibitors of BACEl have been described, most of these compounds are large, polar and do not cross th...
متن کاملProteinase activity regulation by glycosaminoglycans.
There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and glycosaminoglycans is able to modulate the activity of different proteases and also to affect their structures. From the large number of proteases belonging to the well-known protea...
متن کاملNew Applications of Heparin and Other Glycosaminoglycans.
Heparin, the widely used pharmaceutical anticoagulant, has been in clinical use for well over half a century. Its introduction reduced clotting risks substantially and subsequent developments, including the introduction of low-molecular-weight heparin, made possible many major surgical interventions that today make heparin an indispensable drug. There has been a recent burgeoning of interest in...
متن کاملHydrazinolysis of heparin and other glycosaminoglycans.
Heparin, carboxy-group-reduced heparin, several sulphated monosaccharides and disaccharides formed from heparin, and a tetrasaccharide prepared from chondroitin sulphate were treated at 100 degrees C with hydrazine containing 1% hydrazine sulphate for periods sufficient to cause complete N-deacetylation of the N-acetylhexosamine residues. Under these hydrazinolysis conditions both the N-sulphat...
متن کاملCysteine Cathepsin Activity Regulation by Glycosaminoglycans
Cysteine cathepsins are a group of enzymes normally found in the endolysosomes where they are primarily involved in intracellular protein turnover but also have a critical role in MHC II-mediated antigen processing and presentation. However, in a number of pathologies cysteine cathepsins were found to be heavily upregulated and secreted into extracellular milieu, where they were found to degrad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m005993200